NC State
Robert Smart Lab

In order to maintain genomic integrity, cells must respond to DNA damage by engaging the DNA damage response which involves cell cycle arrest, DNA repair and apoptosis. Defects in any one of these responses can lead to mutations and cancer. We have active projects on the roles of basic leucine zipper transcription factors, CCAAT/enhancer binding proteins (C/EBPs) and the long noncoding RNA lincRNAp21 aka TRP53COR1 in 1) regulating the cellular decision to live or die in response to DNA damage or tumor stress, 2) the evasion of apoptosis in tumorigenesis, 3) synthetic lethality and non-oncogene addiction and 4) UVB-induced apoptosis and skin cancer.