NC State
Robert Smart Lab

Kaur, P., R. Barnes, H. Pan, A. Detwiler, M. Liu, C. Mahn, J.R. Hall, Z. Messenger, C.J. You, J. Piehler, R.C. Smart, R. Riehn, P. Opresko, H. Wang.  TIN2 is an architectural protein that facilitates TRF2-mediated trans- and cis-interactions on telomeric DNA. Nucleic Acids Res. 49:13000-13018 2021

Kotlarz, N., J. McCord, D. Collier, M. Stryner, A.B. Lindstrom, A.A. Wilkie, J.Y. Islam, K. Matney, P. Tarte, M.E. Polara, K. Burdette, J. DeWitt, K. May, R.C. Smart, D.R.U. Knappe and J.A. Hoppin. Measurement of Novel, Drinking Water-Associated PFAS in Blood from Adults and Children in Wilmington, North Carolina. Environ. Health Perspect. 128:77005 2020

Tam, H.W., J.R. Hall, Z.J. Messenger, D.D. Jima, J.S. House, K.Linder, and R.C. Smart. C/EBPβ Suppresses Keratinocyte Autonomous Type 1 IFN Response and p53 to Increase Cell Survival and Susceptibility to UVB-induced Skin Cancer. Carcinogenesis. 40:1099-1109 2019

Messenger, Z.J., J.R. Hall, D.D. Jima, J.S. House, H.W. Tam, and R.C. Smart. C/EBPβ deletion in oncogenic Ras skin tumors is a synthetic lethal event. Cell Death and Dis  Oct 15;9(11):1054 2018

Hall, J.R., Z.J. Messenger, H.W. Tam, S.L. Phillips, L. Recio and R.C. Smart. Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis in keratinocytes. Cell Death and Dis Mar 19:6 e1700 2015

Hall, J.R., M.S. Bereman, A.I. Nepomuceno, E.A Thompson, D.C. Muddiman and R.C. Smart. C/EBPα regulates CRL4Cdt2-mediated degradation of p21 in response to UVB-induced DNA damage to control the G1/S checkpoint. Cell Cycle 13:3602-3610 2014

Gaddameedhi, S., C.P. Selby, W.K. Kaufmann, R.C. Smart and A. Sancar. Control of skin cancer by the circadian rhythm. Proc. Natl. Acad. Sci. USA 108:18790-18794 2011

Ming, M., L. Feng, C.R. Shea, K. Soltani, B. Zhao, W. Han, R.C. Smart, C.S. Trempus and Y.Y. He.  PTEN positively regulates UVB-induced DNA damage repair. Cancer Res 71:5287-5295 2011

Thompson, E.A., S. Zhu, J.R. Hall, J.S. House, R. Ranjan, J.A. Burr, Y-Y. He, D.M. Owens and R.C. Smart. C/EBPα expression is downregulated in human nonmelanoma skin cancers and inactivation of C/EBPa confers susceptibility to UVB-induced skin squamous cell carcinomas. J. Invest. Dermatol. 131:1339-1346 2011

Kim, T.H., S.L. Chiera, K.E. Linder, C.S. Trempus, R.C. Smart and J.M. Horowitz. Overexpression of transcription factor Sp2 inhibits epidermal differentiation and increases susceptibility to wound- and carcinogen-induced tumorigenesis.  Cancer Res 70:8507-8516 2010

Omori, E., K. Matsumoto, S. Zhu, R.C. Smart and J. Ninomiya-Tsuji. Ablation of TAK1 upregulates reactive oxygen species and selectively kills tumor cells. Cancer Res 70:8417-8425 2010

Lee, S., J.D. Shuman,  T. Guszczynski, K. Sakchaisri, T. Sebastian, T.D. Copeland, M. Miller, M.S. Cohen, R.C. Smart, Z. Xiao, L.R. Lu, T.D. Veenstra and P.F. Johnson.  RSK-mediated phophorylation in the C/EBPβ leucine zipper regulates DNA binding, dimerizations and growth arrest. Mol. Cell Bio. 11:2621-2635 2010

House, J.S., S. Zhu, R. Ranjan, K. Linder and R.C. Smart C/EBPα and C/EBPβ are required for sebocyte differentiation and stratified squamous differentiation in adult mouse skin PloS ONE 5;9837 2010

Ranjan, R., E. A. Thompson, K. Yoon, R. C. Smart. C/EBPα expression is partially regulated by C/EBPβ in response to DNA damage and C/EBPα-deficient fibroblasts display an impaired G1 checkpoint. Oncogene 28: 3235-45 2009

Ewing, S. J., S. Zhu, F. Zhu, J. S. House and R. C. Smart. C/EBPβ represses p53 to promote cell survival downstream of DNA damage independent of oncogenic Ras and p19Arf. Cell Death and Diff 15 : 1734-1744 2008

Yoon, K., S. Zhu, S. J. Ewing and R. C. Smart. Decreased survival of C/EBPβ -deficient keratinocytes is due to aberrant regulation of p53 levels and function. Oncogene 26 : 360-367. 2007.

Loomis, K. D., S. Zhu, K. Yoon, P. F. Johnson and ,R. C. Smart .Genetic ablation of C/EBPα in epidermis reveals its role in suppression of epithelial tumorigenesis. Cancer Res 67 : 6768-76 2007

Omori, E., K. Matsumoto, H. Sanjo, S. Sato, S. Akira, R. C. Smart, and J. Ninomiya-Tsuji TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis J. Biol. Chem. 281 : 19610-19617. 2006.

Sterneck, E., S. Zhu, A. Ramierz, J. L. Jorcano and R. C. Smart. Conditional ablation of C/EBPβ demonstrates its keratinocyte specific requirement for cell survival and mouse skin tumorigenesis. Oncogene 25 :1272-1276. 2006.

Shim, M., K. L. Powers, S. J. Fry, S. Zhu and R. C. Smart .Diminished expression of C/EBPα in skin carcinomas is linked to oncogenic Ras and re-expression of C/EBPα in carcinoma cells inhibits proliferation. Cancer Res, 65 : 861-867. 2005

Shuman, J. D., T. Sebastian, P. Kaldis, T. D. Copeland, S. Zhu, R.C. Smart and P. J. Johnson. Cell cycle-dependent phosphorylation of C/EBPβ mediates oncogenic cooperativity between C/EBPβ and H-RasV12. Mol. Cell. Bio. 24 : 7380-7391. 2004

Yoon, K. and R. C. Smart. CCAAT/enhancer binding protein-alpha is a DNA-damage inducible p53-regulated mediator of the G1 checkpoint. Mol. Cell. Bio. 24 : 10650-10660. 2004