NC State
Robert Smart Lab

Tam, H.W., J.R. Hall, Z.J. Messenger, D.D. Jima, J.S. House, K.Linder, and R.C. Smart. C/EBPβ Suppresses Keratinocyte Autonomous Type 1 IFN Response and p53 to Increase Cell Survival and Susceptibility to UVB-induced Skin Cancer. Carcinogenesis. 2019 Jan 29

Messenger, Z.J., J.R. Hall, D.D. Jima, J.S. House, H.W. Tam, and R.C. Smart. C/EBPβ deletion in oncogenic Ras skin tumors is a synthetic lethal event. Cell Death and Dis 2018 Oct 15;9(11):1054

Hall, J.R., Z.J. Messenger, H.W. Tam, S.L. Phillips, L. Recio and R.C. Smart. Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis in keratinocytes. Cell Death and Dis Mar 19:6 e1700 2015

Hall, J.R., M.S. Bereman, A.I. Nepomuceno, E.A Thompson, D.C. Muddiman and R.C. Smart. C/EBPα regulates CRL4Cdt2-mediated degradation of p21 in response to UVB-induced DNA damage to control the G1/S checkpoint. Cell Cycle 13:3602-3610 2014

Gaddameedhi, S., C.P. Selby, W.K. Kaufmann, R.C. Smart and A. Sancar. Control of skin cancer by the circadian rhythm. Proc. Natl. Acad. Sci. USA 108:18790-18794 2011

Ming, M., L. Feng, C.R. Shea, K. Soltani, B. Zhao, W. Han, R.C. Smart, C.S. Trempus and Y.Y. He.  PTEN positively regulates UVB-induced DNA damage repair. Cancer Res 71:5287-5295 2011

Thompson, E.A., S. Zhu, J.R. Hall, J.S. House, R. Ranjan, J.A. Burr, Y-Y. He, D.M. Owens and R.C. Smart. C/EBPα expression is downregulated in human nonmelanoma skin cancers and inactivation of C/EBPa confers susceptibility to UVB-induced skin squamous cell carcinomas. J. Invest. Dermatol. 131:1339-1346 2011

Kim, T.H., S.L. Chiera, K.E. Linder, C.S. Trempus, R.C. Smart and J.M. Horowitz. Overexpression of transcription factor Sp2 inhibits epidermal differentiation and increases susceptibility to wound- and carcinogen-induced tumorigenesis.  Cancer Res 70:8507-8516 2010

Omori, E., K. Matsumoto, S. Zhu, R.C. Smart and J. Ninomiya-Tsuji. Ablation of TAK1 upregulates reactive oxygen species and selectively kills tumor cells. Cancer Res 70:8417-8425 2010

Lee, S., J.D. Shuman,  T. Guszczynski, K. Sakchaisri, T. Sebastian, T.D. Copeland, M. Miller, M.S. Cohen, R.C. Smart, Z. Xiao, L.R. Lu, T.D. Veenstra and P.F. Johnson.  RSK-mediated phophorylation in the C/EBPβ leucine zipper regulates DNA binding, dimerizations and growth arrest. Mol. Cell Bio. 11:2621-2635 2010

House, J.S., S. Zhu, R. Ranjan, K. Linder and R.C. Smart C/EBPα and C/EBPβ are required for sebocyte differentiation and stratified squamous differentiation in adult mouse skin PloS ONE 5;9837 2010

Ranjan, R., E. A. Thompson, K. Yoon, R. C. Smart. C/EBPα expression is partially regulated by C/EBPβ in response to DNA damage and C/EBPα-deficient fibroblasts display an impaired G1 checkpoint. Oncogene 28: 3235-45 2009

Ewing, S. J., S. Zhu, F. Zhu, J. S. House and R. C. Smart. C/EBPβ represses p53 to promote cell survival downstream of DNA damage independent of oncogenic Ras and p19Arf. Cell Death and Diff 15 : 1734-1744 2008

Yoon, K., S. Zhu, S. J. Ewing and R. C. Smart. Decreased survival of C/EBPβ -deficient keratinocytes is due to aberrant regulation of p53 levels and function. Oncogene 26 : 360-367. 2007.

Loomis, K. D., S. Zhu, K. Yoon, P. F. Johnson and ,R. C. Smart .Genetic ablation of C/EBPα in epidermis reveals its role in suppression of epithelial tumorigenesis. Cancer Res 67 : 6768-76 2007

Omori, E., K. Matsumoto, H. Sanjo, S. Sato, S. Akira, R. C. Smart, and J. Ninomiya-Tsuji TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis J. Biol. Chem. 281 : 19610-19617. 2006.

Sterneck, E., S. Zhu, A. Ramierz, J. L. Jorcano and R. C. Smart. Conditional ablation of C/EBPβ demonstrates its keratinocyte specific requirement for cell survival and mouse skin tumorigenesis. Oncogene 25 :1272-1276. 2006.

Shim, M., K. L. Powers, S. J. Fry, S. Zhu and R. C. Smart .Diminished expression of C/EBPα in skin carcinomas is linked to oncogenic Ras and re-expression of C/EBPα in carcinoma cells inhibits proliferation. Cancer Res, 65 : 861-867. 2005

Shuman, J. D., T. Sebastian, P. Kaldis, T. D. Copeland, S. Zhu, R.C. Smart and P. J. Johnson. Cell cycle-dependent phosphorylation of C/EBPβ mediates oncogenic cooperativity between C/EBPβ and H-RasV12. Mol. Cell. Bio. 24 : 7380-7391. 2004

Yoon, K. and R. C. Smart. CCAAT/enhancer binding protein-alpha is a DNA-damage inducible p53-regulated mediator of the G1 checkpoint. Mol. Cell. Bio. 24 : 10650-10660. 2004