NC State

Robert Smart Lab

The research in the Smart Lab involves the identification and characterization of genes/signaling pathways that are determinants of susceptibility to cancer, particularly as it relates to gene-environment interactions.  We utilize genetic/molecular/cellular-based systems and powerful genetically engineered mouse models to define mechanisms by which environmental stressors induce cancer.  We are especially interested in how cells respond to DNA damage to maintain genomic integrity and the role of the basic leucine zipper transcription factors, CCAAT/enhancer binding proteins (C/EBPs) and long noncoding RNAs in this process. Our laboratory has identified novel and critical roles for C/EBPs in skin cancer and oncogenic Ras-induced tumorigenesis, the DNA damage response involving the regulation G1/S checkpoint, regulation of p53-mediated apoptosis and keratinocyte and sebocyte differentiation.